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Description
Fc γ RIIB/CD32b His Tag Protein, HumanProduct Specification Species Human Synonyms Fc RIIb, CD32b; Fc gamma Receptor IIB C, CD32, CD32b,CDw32 Accession P31994 1 Amino Acid Sequence Ala46 Pro217, with C terminal His Expression System HEK293 Molecular Weight 27 30 kDa() Purity 98%, by SDS PAGE under reducing conditions Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at less than 1 mg mL
Product Specification
| Species | Human |
| Synonyms | Fc γ RIIb, CD32b;Fc gamma Receptor IIB/C, CD32, CD32b,CDw32 |
| Accession | P31994-1 |
| Amino Acid Sequence | Ala46-Pro217, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 27 -30 kDa(还原状态) |
| Purity | ＞98%, by SDS-PAGE under reducing conditions |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation . |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
IgG Fc receptor (Fc γ R) is a member of the Ig superfamily, which plays a role in activating or inhibiting immune response. Human Fc γ Rs is identified as three types: RI (CD64), RII (CD32) and RIII (CD16). Human Fc γ RII / CD32 has three genes, CD32A, B and C, respectively. CD32 is a low affinity Fc receptor. Low-affinity immunoglobulin Fc γ region receptor II-b, namely CD32b, also known as FCGR2B, FCG2, IGFR2. CD32b was expressed on B cells and myeloid dendritic cells. The co-junction of CD32b on dendritic cells inhibits maturation and prevents cell activation. CD32b may also be a target for monoclonal antibody therapy of malignant tumors.
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